Subunit M2 of mammalian ribonucleotide reductase. Characterization of a homogeneous protein isolated from M2-overproducing mouse cells.
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چکیده
منابع مشابه
Regulation of ribonucleotide reductase M2 expression by the upstream AUGs
Ribonucleotide reductase catalyzes a rate-limiting reaction in DNA synthesis by converting ribonucleotides to deoxyribonucleotides. It consists of two subunits and the small one, M2 (or R2), plays an essential role in regulating the enzyme activity and its expression is finely controlled. Changes in the M2 level influence the dNTP pool and, thus, DNA synthesis and cell proliferation. M2 gene ha...
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BACKGROUND/AIMS Ribonucleotide reductase subunit M2 (RRM2) catalyzes the production of deoxynucleotide triphosphates, which are necessary for DNA synthesis. RRM2 has been reported to play an active role in tumor progression, and elevated RRM2 levels have been correlated with poor prognosis for colorectal cancer patients. This study aimed to elucidate the prognostic significance of RRM2 protein ...
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After approval of imatinib for treatment of chronic myeloid leukemia, molecular-targeted therapies make change of the management strategies against cancers. Many target molecules have been revealed in several cancers such as lung cancer, breast cancer, colorectal cancer, and hematopoietic tumor. Representative molecular-targeted agents are trastuzumab for breast cancer, imatinib and rituximab f...
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Lung cancer is one of the most lethal cancers worldwide. At present, cancer cells metastasis becomes the hot spot. Related studies showed that ribonucleotide reductase small subunit M2 (RRM2) is associated with tumor cell invasion, metastasis, and angiogenesis. It can activate a series of proto-oncogenes to promote tumor growth. This study investigates RRM2 expression and clinical significance ...
متن کاملTargeting ribonucleotide reductase M2 subunit by small interfering RNA exerts anti-oncogenic effects in gastric adenocarcinoma.
Ribonucleotide reductase M2 subunit (RRM2) is one of the two subunits of human ribonucleotide reductase which plays a critical role in tumor progression. The aim of the present study was to analyze its expression, clinical significance and biological functions in gastric adenocarcinoma. We observed the upregulation of RRM2 mRNA and protein in all nine gastric cancer cell lines examined. In pair...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1985
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)89423-6